Abstract. CASTELLANOS, Rafael Gustavo; BARRIOS PERALTA, Elkin; SUAREZ, Jorge and NARINO, Daniel. Focus on adult status epilepticus: Considerations. In adults with convulsive status epilepticus, intramuscular midazolam, Collins JF, Point P. Treatment of status epilepticus if first drug fails. Epilepsia. In elderly patients, refractory status epilepticus (RSE) may lead to death in over to prolonged seizures and status epilepticus. Epilepsia. ;S59–

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Precise epidemiological data for SE are not available for India. All languages were included. Since the majority of seizures are brief, and once a seizure lasts more than 5 minutes it is esstatus to be prolonged 3status treatment protocols have used a 5-minute definition to minimize both the risk of seizures reaching 30 minutes and the adverse fpileptico associated with needlessly intervening on brief, self-limited seizures 24.

Intravenous valproic acid has similar efficacy but better tolerability than IV phenobarbital level B as second therapy after failure of a benzodiazepine.


Patients already receiving AEDs will require some dose escalation or adjustment according to the prevailing blood drug levels.

Patients who did not respond to the first treatment received a second choice of treatment drug and, if necessary, a third choice. The pathophysiology of propofol infusion syndrome: However, two major modifications to the scoring system were made owing to the ethical and logistic difficulties in conducting convulsive status epilepticus trials: A duration of 5 min probably is a reasonable cutoff to distinguish isolated seizures from SE.

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It appears that in SE the innate inhibitory mechanisms in the brain that esttus a halt to the seizure are no longer effective. The minimum time criterion to define SE was reduced from 30 to 5 minutes, defined as continuous seizure activity or rapidly recurrent seizures without resumption of consciousness for more than 5 minutes.

Epilepsia ; 40 1: Status epilepticus in central nervous system infections: There is insufficient data to support or refute recommendations as to whether blood cultures or lumbar puncture should be done on a routine basis in children in whom there is no clinical suspicion of a systemic or CNS infection level U.

The funding is for a study unrelated epipeptico status epilepticus. Bare, have nothing to disclose relevant to this guideline. They can last for hours or epilpetico days. There is no clear evidence to guide therapy in this phase level U.

Revisión del estado epiléptico convulsivo pediátrico y su manejo antiepiléptico

The goal of therapy is the rapid termination of both clinical and electrical seizure activity, since appropriate and timely therapy of status epilepticus reduces the associated mortality and morbidity 9.

SE may pass through five distinct electrographic stages: The resulting studies were reviewed for relevance.

Ajith Cherian and Sanjeev V. Show all Show less. Class III epileptioc identified similar rates of respiratory depression with IV benzodiazepine use 3549 A search of the Cochrane Library yielded four additional completed and relevant published meta-analyses 18— In adults, IM midazolam, IV lorazepam, IV diazepam with or without phenytoinand IV phenobarbital are established as efficacious at stopping seizures lasting at least 5 minutes level A.

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A treatment was successful if the status epilepticus stopped within 20 minutes after infusion started with no recurrence prior to 60 minutes. A landmark meeting in Marseilles in was the first scientific meeting to epiileptico devoted to the topic of SE, and the published proceedings is the first monograph on SE.

Those that persist for more than 30 minutes are more difficult to treat.


Status epilepticus in well-oxygenated rats causes neuronal necrosis. No significant difference in effectiveness has been demonstrated between intravenous lorazepam and intravenous diazepam in adults or children with convulsive status epilepticus Level A.

Proposed treatment algorithm for status epilepticus. It should be used with caution in combination with carbonic anhydrase inhibitors such as zonisamide and topiramate due to the risk of refractory acidosis. Complications Patients with SE are prone to several medical complications. Anticonvulsant therapy for status epilepticus.